Cell-Based Assays

Cell based assays are defined as any assay that takes place within a living cell. Because this definition is so general, there are thousands of different cell based assays.

Gene Editing

Deliver gene editing machinery in the form of mRNA, plasmids or ribonuclear proteins (RNPs) for a variety of nucleases and/or nickases including CRISPR, TALENs and ZFN, to primary cells, iPSCs or cell lines using MaxCyte cell engineering for high efficiency gene knock-in, knockout, correction of genetic disease mutations, or generation of custom bioproduction manufacturing cell lines.

Primary Cells

Over 15 years ago we developed a non-viral delivery platform for cell-engineering that fulfilled the stringent demands of clinical use, including the ability to reproducibly modify primary human cells with high efficiency and low cytotoxicity. Today, these attributes enable the engineering of primary and stem cells for a variety of clinical and research applications.

Protein Production

Rapidly produce proteins and antibodies in your biomanufacturing host to identify and characterize top candidates without the time or cost of stable cell line development. Enjoy the ultimate in production system flexibility, performance and scalability that supports R&D through cGMP pilots and toxicology studies.

Stem Cells

Over 15 years ago we developed a non-viral delivery platform for cell-engineering that fulfilled the stringent demands of clinical use, including the ability to reproducibly modify primary human cells with high efficiency and low cytotoxicity. Today, these attributes enable the engineering of primary and stem cells for a variety of clinical and research applications.

TCR / CAR

MaxCyte cell engineering enables high-performance, ex vivo modification of PBMCs, T cell, NK cells and other novel immune cell populations, at clinical scale in support of the development and commercialization of highly efficacious, autologous or allogeneic adoptive cell therapies. Highly sophisticated, multiplexed engineering, such as chimeric antigen receptor (CAR) expression, checkpoint inhibitor knockdown, T cell receptor (TCR) disruption, and chemokine reception expression, is made possible using mRNA transfection or delivery of other gene editing machinery such as CRISPR/Cas9, Sleeping Beauty, Piggy Bac or other transposon systems.

Ion Channels

Ion channels are protein molecules that span across the cell membrane allowing the passage of ions from one side of the membrane to the other. They have an aqueous pore, which becomes accessible to ions after a conformational change in the protein structure that causes the ion channel to open.

Reporter Gene Assay

Reporter genes have become an invaluable tool in studies of gene expression. They are widely used in biomedical and pharmaceutical research and also in molecular biology and biochemistry.

GPCR

G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein-linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times

Kinases

In biochemistry, a kinase is an enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specific substrates. This process is known as phosphorylation, where the substrate gains a phosphate group and the high-energy ATP molecule donates a phosphate group.

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