We provide our patented, high-performance cell-engineering platform to biopharmaceutical partners engaged in drug discovery and development, biomanufacturing and cell therapy, including gene editing and immuno-oncology. With our robust delivery platform, our team of scientific experts helps our partners unlock the potential of their products and solve development and commercialization challenges.
This platform allows for the engineering of nearly all cell types, including human primary cells, with any molecule, at any scale. It also provides unparalleled consistency and minimal cell disturbance – facilitating rapid, large-scale, clinical- and commercial-grade cell-engineering in a non-viral system and with low-toxicity concerns. Our cell-engineering platform is FDA-cleared, providing our customers and partners with an established regulatory path to commercialize cell-based medicines.
MaxCyte has developed CARMA®, a novel and proprietary technology for the development of non-viral, mRNA-based cell therapies. CARMA enables highly efficient, non-viral, delivery of one or more mRNA into unstimulated immune cells. CARMA offers the potential for a safer cell therapy, as a result of transient expression and a non-viral delivery approach. Together, CARMA and the EXPERT™ family of instruments also offer the potential for a one-day, scalable, and cost-effective GMP manufacturing process without the complexity of virus-based products.
At MaxCyte, we take a collaborative partnering approach with our clients with the goal of rapidly driving our partners’ development efforts forward through to commercial use, more cost-effectively and with lowered risk.
Our broad intellectual property (IP) portfolio, along with our regulatory certifications and support, offer our partners both enhanced IP protection and freedom to operate.
Scientists are just beginning to unravel the complexities of cells, their regulation, and their relationship to disease. As our understanding continues to grow, it reveals new avenues for therapeutic interventions and curative efforts.
Cell-engineering looks to unlock the power of cells for a variety of applications including the discovery, development, and manufacture of novel small molecule drugs and biologics, the biomanufacturing of vaccines and biotherapeutics, the re-direction or enhancement of cells for use as cellular therapies, and the modification of targeted genes in cells for therapeutic purposes through genomic editing.
We have developed and commercialized MaxCyte Scalable Transfection Systems for high-performance delivery of biomolecules using Flow Electroporation ® Technology, a proprietary cell-engineering technology designed to meet the stringent demands of clinical use – namely, the ability to safely and reproducibly modify primary human cells with high efficiency, low cytotoxicity, and at the scale required to treat patients.
Flow Electroporation Technology leverages a fundamental property of cells – the reversible permeability of membranes in the presence of an electrical charge – to create a transformative method for universally delivering molecules such as nucleic acids and proteins into cells, turning cells into drugs,and individualized therapies.
Unlike other methods, Flow Electroporation Technology is a fully scalable, delivery platform that enables small-scale R&D through large-scale cell-engineering for global patient treatment. It is the leading non-viral delivery platform for cell-engineering in clinical use with an approved commercial immunotherapy in Japan and is currently being used in over 10 clinical trials.
We pair our high-performance delivery platform with our cell-engineering expertise to accelerate the discovery, development and manufacturing of next-generation, cell-based medicines – overcoming client challenges and enabling previously unfeasible cell-engineering applications.
As a company, we are dedicated to advancing cell-engineering through application of our patented delivery platform and collaborative partnerships. We are uniquely positioned at the center of cell therapy and gene editing — able to unlock the full power of the human cell to maximize the potential of these promising modalities.