Development of a genome-wide CRISPR screen in CD4+ T cells to identify drug targets for immune-mediated inflammatory diseases

2021-04-13T17:39:43+00:00April 12th, 2021|Comments Off on Development of a genome-wide CRISPR screen in CD4+ T cells to identify drug targets for immune-mediated inflammatory diseases

CCR5-edited CD4+ T cells augment HIV-specific immunity to enable post-rebound control of HIV replication

2021-06-25T17:18:44+00:00February 11th, 2021|Comments Off on CCR5-edited CD4+ T cells augment HIV-specific immunity to enable post-rebound control of HIV replication

Genome-Wide Analysis of Off-Target CRISPR/Cas9 Activity in Single-Cell-Derived Human Hematopoietic Stem and Progenitor Cell Clones

2021-06-25T17:05:46+00:00November 11th, 2020|Comments Off on Genome-Wide Analysis of Off-Target CRISPR/Cas9 Activity in Single-Cell-Derived Human Hematopoietic Stem and Progenitor Cell Clones

Scalable Manufacturing and Nanovesicle Delivery of CRISPR-Cas9 Ribonucleoproteins Using a cGMP- Compliant Cell Engineering Platform

2021-03-24T15:37:30+00:00November 2nd, 2020|Comments Off on Scalable Manufacturing and Nanovesicle Delivery of CRISPR-Cas9 Ribonucleoproteins Using a cGMP- Compliant Cell Engineering Platform

Beyond affinity: selection of antibody variants with optimal biophysical properties and reduced immunogenicity from mammalian display libraries

2021-06-25T17:46:45+00:00June 9th, 2020|Comments Off on Beyond affinity: selection of antibody variants with optimal biophysical properties and reduced immunogenicity from mammalian display libraries

CRISPR-mediated Mutation Correction of Hematopoietic Stem Cells from Patients with X-linked Chronic Granulomatous Disease Using Non-Viral Cell Engineering

2020-07-07T16:05:23+00:00May 16th, 2020|Comments Off on CRISPR-mediated Mutation Correction of Hematopoietic Stem Cells from Patients with X-linked Chronic Granulomatous Disease Using Non-Viral Cell Engineering
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