Guide Select™
Screening Assay
SeQure Dx's Guide Select is a biochemical screening assay based on the ONE-seq platform that enables variant aware off-target risk assessment for multiple guide RNAs in parallel. Guide Select enables you to de-risk development of your cell and gene therapy at an early stage by identifying potential off-target effects with high sensitivity and precision. This data-driven approach helps optimize guide RNA selection and streamline the development process, saving time and resources while supporting efficient therapeutic development.
Guide Select Overview
Guide Select
Multiplexed off-target assessment assay designed for screening multiple guide RNAs in parallel. Variant aware searching within a limited search space enables high powered, low-cost surface-level risk assessment for program prioritization and guide RNA selection.
In silico + biochemical evaluation
- Low cost per guide
- Screen high similarity off-targets
- Population-scale variant assessment
Informed guide RNA selection
- Evaluate multiple guides
- Reduce program risk through early profiling and selection
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