Guide Profiler™

Screening Assay

Our in silico Guide Profiler tool enables rapid screening of multiple guide RNAs in parallel, allowing researchers to identify potential off target effects and narrow down candidates during early discovery and target validation.

Guide Profiler Overview

SDX-Guide Profiler Overview

Guide Profiler

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In silico preview of potential off-target effects associated with your gene editing tool. Enables you to start your gene editing risk assessment by rapidly screening sgRNAs to understand the on- and off-target editing risks. Integrates with downstream assays, including Guide Select and ONE-seq for additional cost savings.

In silico evaluation​
Preview of off-target risk

  • Rapid turn around time
  • Flows seamlessly into Nomination assays
  • Comprehensive report

Rapidly screen candidate guides

  • Minimize risk from variation at on-target locus
  • Benchmark against database of guides

Featured Resources

Guide Profiler-A Genetic Variant-Aware Computational Tool for Improved Guide RNA Selection for CRISPR-based Therapeutic Applications-Figure 1G
Poster
Guide Profiler: A Genetic Variant-Aware Computational Tool for Improved Guide RNA Selection for CRISPR-based Therapeutic Applications
SDX-Guide select report
Example Report
Guide Select Screening Assay Example Report
ONE-seq for Variant-Aware Therapeutic Guide Selection-One-seq incorporates global human genetic diversity
Poster
ONE-seq for Variant-Aware Therapeutic Guide Selection
View All Resources
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Related Screening Assays

Guide Select

Off-target assessment assay designed for screening multiple guide RNAs in parallel. Variant aware searching within a limited search space enables high powered, low-cost risk assessment for guide RNA selection.

Discover a comprehensive suite of assays spanning from early discovery through pre-clinical and clinical development.

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