ONE-seq®
Nomination Assay
SeQure Dx's ONE-seq is the gold-standard nomination assay for comprehensive identification of all putative on- and off-target effects for your gene editing tool of interest. ONE-seq leverages variant aware off-target enumeration coupled with in vitro cutting and deep sequencing to enable precise identification of on- and off-target edits across distinct genetic sub-populations. This high-powered assay offers the most comprehensive risk assessment available for gene editing, ensuring unparalleled confidence in your therapeutic development.
ONE-seq Overview
ONE-seq
Gold-standard population-scale variant-aware off-target detection. Candidate off-target enumeration, enrichment, and biochemical IVC combined with deep sequencing results in high sensitivity to low frequency off-target events. Features fully annotated reporting.
Nomination
Comprehensive off-target assessment
- Highly sensitive
- Universal for all editors
- Population-scale variant assessment
Off-Target Assessment
Guide RNA Selection
IND Filings
- Multiple orthogonal methods
- Variant effect prediction
- GLP
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