ONE-seq
Nomination assay
SeQure's ONE-seq is the gold standard nomination assay for comprehensive identification of all putative on- and off-target effects for your gene editing tool of interest. ONE-seq leverages variant-aware off-target enumeration coupled with in vitro cutting and deep sequencing to enable precise identification of on- and off-target edits across distinct genetic sub-populations. This high-powered assay offers the most comprehensive risk assessment available for gene editing, ensuring unparalleled confidence in your therapeutic development.
ONE-seq overview
ONE-seq
Gold standard population-scale, variant-aware, off-target detection. Candidate off-target enumeration, enrichment and biochemical IVC combined with deep sequencing results in high-sensitivity to low-frequency off-target events. Features fully annotated reporting.
Nomination
Comprehensive off-target assessment
- Highly sensitive
- Population-scale variant assessment
Off-target assessment
Guide RNA selection
IND filings
- Multiple orthogonal methods
- Variant effect prediction
Related nomination assays
Learn more about our comprehensive suite of assays spanning from early discovery through pre-clinical and clinical development.
