CAR T Cell Manufacturing
Partner with MaxCyte® to navigate the challenges of CAR T cell manufacturing. With us, you can achieve highly efficient delivery of gene editing constructs to difficult-to-transfect primary T cells while maintaining cell viability. With our scalable electroporation technology, you can streamline the development of CAR T cell therapy from concept to commercialization.
High knockin efficiency at the TRAC locus with MaxCyte electroporation.
This content was reproduced with the kind permission of Alexander Marson, bioRxiv 2021.09.02.458799.
Enable highly efficient targeted knockin
Efficient integration of CAR genes into targeted sites such as the T Cell Receptor Alpha Constant (TRAC) locus has proved challenging even with precision genome engineering tools. MaxCyte enables delivery of diverse payloads resulting in highly efficient integration efficiencies. Discover effortless CAR T cell engineering with MaxCyte.
Achieve seamless scalability
Although CAR T cell therapies hold promise for cancer treatment, this approach is fraught with obstacles such as extended development timelines and costly manufacturing. Explore how MaxCyte enabled the cGMP manufacture of stable CAR T cells with enhanced anti-tumor activity in only five days.
nS/MARt vector expressing the CEA-CAR delivered with high efficacy and viability into activated human CD3+ cells.
This content was reproduced with the kind permission of Richard Harbottle.
CAR T Cell manufacturing success with MaxCyte
Genetically engineering T cells to express CARs that recognize tumor-associated antigens is an approach that holds immense potential for treating cancer. Chart a course to success by partnering with us to navigate development and manufacturing challenges.
Research Applications
Related Resources
Electroporation Systems
Supported by numerous publications and clinical trials, our ExPERT GTx® instrument is the next generation of the industry’s leading, scalable electroporation technology for complex cellular engineering.
The GTxTM is capable of high-performance delivery of virtually any molecule, into any cell, at any scale with the unique ability to transfect primary cells, stem cells and cell lines with high viability and transfection efficiencies routinely over 90%.
Reagents and Processing Assemblies
MaxCyte’s consumable products provide users with a variety of options for project scale and throughput from discovery through cGMP manufacturing using a single platform. Our range of Processing Assemblies allows users to transfect a variety of cell sample volumes to meet specific application needs. MaxCyte’s Electroporation Buffer is animal-derived component free and safe for all cell types ensuring consistent, high-performance transfection.
Ready to learn more about our technology?
Find out how the ExPERT platform can accelerate your CAR T cell manufacturing journey.
